Urinary Excretion of Nicotinic Acid in Pellagrins

نویسندگان

  • B. Naganna
  • K. V. Giri
  • P. Venkatesam
چکیده

AVhen the identification of pellagra-preventive factor with nicotinic acid, and the therapeutic value of nicotinic acid and its amide in the treatment of pellagra became established, it was desirable to devise methods for their quantitative determination in urine, in order to provide useful information in clinical investigations and for assessing the level of nutrition with respect to nicotinic acid, similar to those already in use for vitamin C and vitamin Bx. Various methods have been suggested for the quantitative determination of nicotinic acid. All these methods are based on the reaction in

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

CHEMICAL DETERMINATION AND URINARY EXCRETION OF THE METABOLITE Nr-METHYLNICOTINAMIDE

Independent studies in two laboratories have led to the development of chemical tests for the early diagnosis of pellagra. Melnick and associates (l-3) reported the excretion in urine of a compound which fails to react like nicotinic acid or amide with cyanogen bromide and aniline (Koenig reaction) unless previously subjected to alkaline hydrolysis. The physical and chemical similarity of the m...

متن کامل

F(1) and F(2) of Najjar and Holt in the Urine of Normal Young Men.

Najjar and Holt (1, 2) have demonstrated that their fluorescent urinary pigments, F1 and F2, are related to nicotinic acid metabolism in such a way that their estimation in urine is of diagnostic use in human pellagra (1) and in canine black tongue (1, 2). As nicotinic acid deficiency progresses, the daily excretion of F1, starting from a low level, slowly rises and then falls again; and the da...

متن کامل

Studies of the Urinary Excretion of Nicotinic Acid in Diabetic Patients

In a recent paper, Banerjee, Ghosh and Bhattacharya (1948) have developed a method using Koenig's (1904) basic reaction for the estimation of nicotinic acid in urine in the presence of sugar. It represents a simplification of' the earlier methods of Melnick and Field (1940), Swaminathan (1939), Harris and Raymond (1939) and several others. An interest in the study of urinary excretion of nicoti...

متن کامل

Quinolinic acid excretion and metabolism in man.

In 1946, Rosen e2 al. (1) showed that administration of tryptophan to rats resulted in an additional excretion of nicotinic acid and Nl-methylnicotinamide (Nl-Me). Singal et al. (2) found, in addition to these, increased excretion of another metabolite which could be converted to nicotinic acid by autoclaving in 1 N sulfuric acid solution. Henderson isolated this metabolite from the urine of ra...

متن کامل

The effect of tryptophane on the urinary excretion of nicotinic acid in rats.

Krehl et al. (1,2) have observed a growth retardation in rats when large amounts of corn grits were included in a low protein ration. The addition of either Z(-)-tryptophane or nicotinic acid corrected the deficiency and allowed normal growth to proceed. The beneficial action of tryptophane has also been observed in nicotinic acid deficiency in the chick (3) and the mouse (4). Although recent r...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 76  شماره 

صفحات  -

تاریخ انتشار 1941